Decellurization is an absolutely fascinating process in which cells are “discharged” from organs, leaving only the connective tissue.
The first step involves the application of a specialized detergent known to be an efficient solubilizer, without affecting the integrity of the protein in the tissue. Then, a recombinant endonuclease is used to degrade nucleic acids. (I had to quote Wiki there because I’m pretty sure there was no other way to get the word “solubilizer” into your day today)

This process has tremendous implications for organ donation and transplants, as it maintains structural function yet greatly reduces the immunological response that causes organs to be rejected. It can be done by pumping the detergent through the organ, or submerging the organ.

Science!
If you are as captivated by this as I am, don’t miss the work of Iori Tomita and Brandon Ballengee.



























