Decellurization

Decellurization is an absolutely fascinating process in which cells are “discharged” from organs, leaving only the connective tissue.

tumblr_n9s5jyWVkr1tgoke4o1_500

The first step involves the application of a specialized detergent known to be an efficient solubilizer, without affecting the integrity of the protein in the tissue. Then, a recombinant endonuclease is used to degrade nucleic acids. (I had to quote Wiki there because I’m pretty sure there was no other way to get the word “solubilizer” into your day today)
DecellularizationPorcineHeart

This process has tremendous implications for organ donation and transplants, as it maintains structural function yet greatly reduces the immunological response that causes organs to be rejected. It can be done by pumping the detergent through the organ, or submerging the organ.
decellularization-organ-comparison

Science!

If you are as captivated by this as I am, don’t miss the work of Iori Tomita and Brandon Ballengee.

Advertisements

8 Responses to “Decellurization”

  1. So strange… they look like Greek statues. Imagine if an old statue toppled over, shattered and these things spread all over the floor!

  2. bettiemuldoon Says:

    When I first saw this I nearly blanched. Fascinating, and really neat to see. Almost looks like some sort of plastination process for preserving and studying tissue.

  3. “Yes, but how do they taste?” says a cannibal somewhere.

  4. Cool and a bit spooky for some reason. But even cooler because of the retained functionality!

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: